SAP Advanced Planning and Optimization (SAP APO) is the planning component that, together with SAP Event Management (SAP EM) and SAP Inventory Collaboration Hub (SAP ICH), makes up the SAP SCM solution.
The mySAP SCM Solution suite is complete and heuristic, spanning from supply chain planning and execution to collaboration, visibility and performance management.
Structure of the mySAP SCM solution
Supply Chain Planning contains demand planning, (cross-plant) distribution and procurement planning, and detailed production planning down to operation level. apofrajeis These functions can be executed in SAP ERP Central Component (SAP ECC) (previously version: SAP R/3) and/or in SAP SCM in the components SCM DP, SCM SNP and SCM PP/DS in SAP APO.
Supply Chain Execution contains planning execution as part of manufacturing. Materials Management also falls into this area. mySAP ERP Central Component (ECC) or SAP ECC play a central role in these functions.
Supply Chain Visibility is a key area of the mySAP SCM solution and is composed of Supply Chain Event Management (SCEM) and Supply Chain Performance Management (SCPM).
Supply Chain Collaboration is a key area in the mySAP SCM solution that supports collaborative planning and the exchange of documents with suppliers and customers. Collaborative planning can be done in the SAP Inventory Collaboration Hub (SAP ICH) or in SAP AP dailyvesting with demand in the global chain by balancing push and pull network-planning processes and by handling replenishment and production based on actual demand.
SAP Advanced Planning & Optimization (APO) is consisted of the following components:
APO DP: Improves the forecast quality and planning accuracy
APO SNP: Improves visibility across your global chain and lowers inventory
APO PP/DS: Supports you in creating optimized production plans
APO gATP: Allows state-of-the-art sales order confirmation planning processes
APO TP/VS: Optimizes transportation loads and minimizes transportation costs
APO Alert Monitor: Powerful exception message system integrated in all APO planning modules
APO DP (Demand Planning):
Calculate and determine future demand to improve demand quality and accuracy. Improved forecast quality by using one tool for power and business user and consolidated demand plan (different regions, countries, departments, for example)
APO SNP (Supply Network Planning):
Calculates quantities to be produced and delivered to the locations to match customer demand and maintain desired service levels. To increased visibility over the overall supply chain and optimized sourcing and capacity utilization. SNP also reduced inventory levels and improved customer service.
APO PP/DS (Production Planning & Detailed Scheduling):
PP (Production Planning) delivers a short term plan that matches overall supply to demand, given available resources and production methodology.
And DS (Detailed Production Scheduling) determines optimal production sequence for execution to meet delivery commitments based on actual constraints on the shop floor.
APO PP/DS determines how, callgirlslucknow when, and where resources and materials should be deployed to accomplish the production goals and Master planning for materials
APO gATP (global Available-to-Promise):
Online information about the most recent state of plan allows order promising that will execute after the customers’ expectation. Meet the demand communicated throughout the supply chain with the best sourcing for the available inventories in the supply chain and to sell only what you can actually sell.
APO TP/VS (Transportation Planning / Vehicle Scheduling):
Plan and optimize shipments for orders (sales orders, purchase orders, returns, and stock transport orders) and deliveries. Reduction of transportation costs via advanced planning algorithm. Utilization of vehicles can be optimized. Clear visibility of vehicles / resources / demands and optimized Shipments in terms of lowest transportation costs
APO VMI (Vendor Managed Inventory):
Allows efficient management of the supply chain by managing customer inventory replenishment with automated collaboration. Reduction of stock-outs, rush orders and supply bottlenecks and improved cooperation to the customers and delivery service level.
APO Alert Monitor:
Powerful exception message system integrated in all SAP APO planning modules. First task of the day for a planner: Check the existing alerts. Drill-down from the alert monitor to the application to solve the issue, for example.
This article is a part of SAP APO information. If you are now searching for SAP APO or SAP SCM resource, please check out my website and join my community that gives you the up to date information. Please visit Execute Help On SAP ERP Sincerely, Peeraphat J.
While there is no cure or definitive cause of Alzheimer’s disease, researchers have been focusing on genetic links which may contribute to this disease. Researchers have found one particular gene which they believe to be a risk factor for developing late-onset Alzheimer’s disease in those who inherit it.
This gene is the geschenke-geschenkideen “APOE gene” or “apolipoprotein E gene” of which there are three types called “alleles” that are the most commonly found: “APOE e2, APOE e3, and APOE e4.” It is the “APOE e4” gene that researchers have determined to be the gene which increases the risk for Alzheimer’s.
One APOE allele is inherited from each biological parent and if an individual inherits one or two of the APOE e4 gene they are at a greater risk for developing Alzheimer’s disease however, this does not mean that the individual will acquire the disease for certain.
People who inherit two of the APOE e4 are at a greater risk however, some of these individuals never show symptoms while others who do not even have this particular gene at all develop Alzheimer’s. Therefore the level of risk for an individual who is carrying the APOE e4 gene can not be determined which is why these genes are only considered as risk factors.
APOE Research and Testing
While blood testing is done for the APOE genes, even if an individual has the APOE e4 gene this cannot determine whether or not they will acquire Alzheimer’s disease however, this testing can be useful for researchers as they can then do further testing by looking for any characteristics of Alzheimer’s in the brain of individuals with the APOE e4 gene.
This testing is generally not used in the diagnosis of Alzheimer’s disease however, decorsmag in some cases where a medical evaluation has determined that an individual most likely has this disease; this test may be used in combination with other medical testing to solidify the diagnosis.
About the Author: Anne Ahira is an established entrepreneur and successful coach in her country of Indonesia. Her success story has been published in many nationwide publications in Indonesia.
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Cognitive decline in old age has been described throughout history. However, it was not until the early part of the 20th century that a collection of brain cell abnormalities was specifically identified by a German physician, Alois Alzheimer, for whom the dread disease was named.
Nearly a century later, a high risk for Alzheimer disease was associated with the Apo E 4 gene. Immediately following this discovery, ethical dilemmas associated with genetic testing led to the conclusion that medical records should be kept private in order to protect the rights of patients. Guidelines for genetic testing for Alzheimer disease determined that individuals should not be tested without their primary medical providers’ support and guidance. In 1997, President Clinton proposed a law that would help make it a crime for employers or insurance companies to discriminate on the grounds of genetic testing data they obtained. While his proposal did not become law, half the states in the United States have adopted this policy.
Not all people with Apo E 4 develop Alzheimer disease, especially those who have created a gene-supportive environment. But without that, 90 percent of the 4/4 combination and 49 percent of the 4/3 and 4/2 variants develop the disease. This is a relatively exclusive Apo E club since it is estimated that only 5 percent of the population has the Apo E 4/4. The percentage of the population with the Apo E 4/3 and 4/2 genotype totals 20 percent.
Conversely, not all people with Alzheimer disease have the Apo E 4 genotype. What I do know from my clinical practice is that Apo E 4s who eat a high-fat diet have a very high cholesterol level. My patients with two copies (Apo E 4/4) consistently have total cholesterol levels in the 300s and 400s with LDL in the 200s and 300s. ehabcenter Extremely high levels of LDL (bad) cholesterol cause high levels of inflammation in the blood vessels, including those in the brain. Therefore, a connection between Alzheimer disease and one’s diet is not surprising.
As with all chronic diseases, Alzheimer disease results from the interaction of genetic, environmental, and lifestyle factors over many years, causing changes in brain structure and function. While it is a complex disease with no single, clear-cut cause, for those with a 4/4 genotype, careful matching of your nutritional environment will likely postpone or prevent the development of Alzheimer disease.
In summary, of the many theories about this disease-from toxic factors like aluminum or zinc to smoking being the causative agent-having an Apo E 4 gene (or two) seems to have the strongest connection with Alzheimer disease and provides a connection between elevated cholesterol and fats, with a resulting cellular inflammatory process in the brain.
In my clinical practice I am often able to discern trends in diseases. From these examples, I hope that you can see that the Apo E gene is a powerful component of our total genetic blueprint-a major factor in our overall state of health. For this reason, I believe this gene will be the focus of much future research in the areas where it interacts with our specific environment-our diet, exercise, thought patterns, and any medications we’re taking, as well as its connection with heart disease, cancer, and many other chronic diseases, especially those involving the immune system.
In my opinion not enough attention is being paid to the nutritional connection of these diseases with the Apo E gene. With more attention paid to that connection and with the right nutritional adjustments, reducing the risk of chronic disease is possible, and the risk of cardiovascular disease and Alzheimer disease in particular can be lowered.
Furthermore, I think the risk for Apo E 4 genotypes extends beyond just Alzheimer disease and heart disease. Given that my clinical experience has shown that patients with certain genotypes have certain disease clusters or associated illnesses, the development of many chronic illnesses may turn out to stem from imbalances within each Apo E genotype and how the person’s environment supports (or doesn’t) their specific genotype.
Pamela McDonald is a leading Integrative Medicine Nurse Practitioner, who specializes in the prevention of heart and Alzheimer’s disease, and chronic illness. To learn more about her ground breaking book, and program